La Romana is the seventh-largest city in the Dominican Republic. The city is a hub for a growing tourist industry with several nearby local resort spots, such as the beachfront Bayahibe, Dominicus, Casa de Campo, and the growing number of golf resorts that surround the area.

Punta Cana is part of the newly created Punta Cana-Bávaro-Veron-Macao municipal district in La Altagracia, the easternmost province of the Dominican Republic. The area is best known for its beaches and balnearios, which face both the Caribbean and Atlantic, and it has been a popular tourist destination since the 1970s. The Punta Cana area has an estimated population of 100,000 with a growth rate of 6%. To the north, it borders the village and beach of Cabeza de Toro, and then the Bávaro and El Cortecito beaches. The nearest city, the 500-year-old capital of the Province Higüey, is 45 kilometres (28 mi) away, and it takes about an hour to drive there. Europeans, particularly Spanish hotel chains, own all but two of the 50+ megaresorts of the Punta Cana tourism destination. 

Santo Domingo, known officially as Santo Domingo de Guzmán, is the capital and largest city in the Dominican Republic. Its metropolitan population was 2,084,852 in 2003, and estimated at 2,253,437 in 2006. The city is located on the Caribbean Sea, at the mouth of the Ozama River. Founded by Bartholomew Columbus in 1496, it is the oldest continuously inhabited European settlement in the Americas, and was the first seat of Spanish colonial rule in the New World. It lies within the boundaries of the Distrito Nacional (D.N.; "National District"), itself bordered on three sides by Santo Domingo Province. 

San Felipe de Puerto Plata, Puerto de Plata, often referred to as simply Puerto Plata, is the ninth-largest city in the Dominican Republic, and capital of the province of Puerto Plata. The city serves as one of the most important trading ports in the country. Puerto Plata is famous for resorts such as Playa Dorada and Costa Dorada, located east of San Felipe de Puerto Plata. There are a total of 100,000 hotel beds in the city. The only aerial tramway in the Caribbean is located in Puerto Plata, in which visitors can ride up to the Pico Isabel de Torres, a 793 meter high mountain within the city. The amber museum, is also a well-known attraction in this city. La Isabela, a settlement built by Christopher Columbus, is located near Puerto Plata.