Sitting on Missouri's western border, with Downtown near the confluence of the Kansas and Missouri Rivers, Kansas City is the largest city in the U.S. State of Missouri and the sixth largest city in the Midwest. It is the anchor city of the Kansas City metropolitan area, which straddles the Kansas–Missouri border. Founded in the 1830s, the modern city has several distinguished neighborhoods, each with its own rich history, such as: one of America's largest public farmers' markets located in the River Market District in the north, the cradle of a distinctive form of jazz in the 18th and Vine District in the east, and the Spanish-styled architecture and upscale shops of the Country Club Plaza in the south. Kansas City is also known for its cuisine (most notably its distinctive style of barbecue), its craft breweries, and its major league sports teams.

Indianapolis is the capital of the U.S. state of Indiana, and the county seat of Marion County, Indiana. It is Indiana's largest city and is the 14th largest city in the U.S., the third largest city in the Midwest (behind Chicago and Detroit), the second most populous state capital (after Phoenix, Arizona), and the most populous state capital east of the Mississippi River. The city is also known as the "Racing Capital of the World" due to the proximity of the Indianapolis Motor Speedway, home of the Indy 500 and Allstate 400 at the Brickyard (formerly known as the "Brickyard 400").

Boston is the capital of and largest city in Massachusetts, and is one of the oldest cities in the United States. The largest city in New England, Boston is regarded as the unofficial "Capital of New England" for its economic and cultural impact on the entire "New England" region. The city proper had a 2009 estimated population of 645,169, making it the twentieth largest in the country. It is also the anchor of a substantially larger metropolitan area called  "Greater Boston", home to 4.5 million people and the tenth-largest metropolitan area in the country. Greater Boston as a commuting region includes six Massachusetts counties:  "Essex", "Middlesex","Norfolk", "Suffolk", "Plymouth", "Worcester", northern "Bristol" County, all of "Rhode Island" and parts of "New Hampshire"; it is home to 7.6 million people, making it the fifth-largest Combined Statistical Area in the United States.

Houston is the fourth-largest city in the United States of America and the largest city in the state of Texas. As of the 2009 U.S. Census estimate, the city had a population of 2.3 million within an area of 579 square miles (1,500 km2). Houston is the seat of Harris County and the economic center of the Houston–Sugar Land–Baytown metropolitan area—the sixth-largest metropolitan area in the U.S. with a population of approximately 5.9 million. The city’s relatively compact Downtown includes the Theater District, home to the renowned Houston Grand Opera, and the Historic District, which pairs 19th-century architecture with trendy restaurants.

Tucson is a city in and the county seat of Pima County, Arizona, United States. The city is located 118 miles (188 km) southeast of Phoenix and 60 miles (98 km) north of the U.S.-Mexico border. The 2009 Census Bureau estimate puts the city's population at 543,910, with a metropolitan area population at 1,020,200 as of July 1, 2009. In 2009, Tucson ranked as the 32nd largest city and 52nd largest metropolitan area in the United States. Tucson is the largest city in southern Arizona, the second largest in the state after Phoenix. It is also the largest city in the area of the Gadsden Purchase. Tucson is home to the University of Arizona. Roughly 150 Tucson companies are involved in the design and manufacture of optics and optoelectronics systems, earning Tucson the nickname Optics Valley.

San Francisco, officially the City and County of San Francisco, is the financial, cultural, and transportation center of the San Francisco Bay Area, a region of 7.5 million people which includes San Jose and Oakland. The only consolidated city-county in California, it encompasses a land area of about 46.9 square miles (121 km2) on the northern end of the San Francisco Peninsula, giving it a density of about 17,179 people per square mile (6,632 people per km2). It is the most densely settled large city (population greater than 200,000) in the state of California and the second-most densely populated large city in the United States after New York City. San Francisco is the fourth most populous city in California and the 13th most populous city in the United States, with a population of 805,235 as of the 2010 Census. The San Francisco-Oakland-Fremont metropolitan area has a population of 4,335,391.

Jacksonville is the largest city by population in the U.S. state of Florida, the 12th most populous city in the United States and the largest city by area in the contiguous United States. It is the county seat of Duval County, with which the city government consolidated in 1968. Jacksonville is in the First Coast region of northeast Florida and is centered on the banks of the St. Johns River, about 25 miles (40 km) south of the Georgia state line and about 340 miles (550 km) north of Miami. The Jacksonville Beaches communities are along the adjacent Atlantic coast. Its riverine location facilitates two United States Navy bases and the Port of Jacksonville, Florida's third largest seaport. Significant factors in the local economy include services such as banking, insurance, healthcare and logistics. A regional business center, it also has many museums and cultural offerings.

Milwaukee is the largest city in the State of Wisconsin and the fifth-largest city in the Midwestern United States. The county seat of Milwaukee County, it is on Lake Michigan's western shore. According to the 2010 census, Milwaukee has a population of 594,833. Milwaukee is the main cultural and economic center of the Milwaukee–Racine–Waukesha Metropolitan Area with a population of 2,043,904 as of an official 2014 estimate. Known for its brewing traditions, major new additions to the city include the Milwaukee Riverwalk, the Wisconsin Center,Miller Park, an expansion to the Milwaukee Art Museum, Milwaukee Repertory Theater, and Pier Wisconsin, as well as major renovations to the UW–Milwaukee Panther Arena. In addition, many new skyscrapers, condos, lofts and apartments have been built in neighborhoods on and near the lakefront and riverbanks.

Omaha is the largest city in the state of Nebraska, United States, and is the county seat of Douglas County. It is located in the Midwestern United States on the Missouri River, about 20 miles (30 km) north of the mouth of the Platte River.  A stop on the Lewis & Clark National Historic Trail, it's known for its pioneer history, museums and cultural centers.  The modern economy of Omaha is diverse and built on skilled knowledge jobs. In 2009, Forbes identified Omaha as the nation's number one "Best Bang-For-The Buck City" and ranked it number one on "America's Fastest-Recovering Cities" list. Tourism in Omaha benefits the city's economy greatly, with the annual College World Series providing important revenue and the city's Henry Doorly Zoo serving as the top attraction in Nebraska as well as being named the best zoo in the world by Trip Advisor in 2014.

Albuquerque is the largest city in the state of New Mexico, United States. It is the county seat of Bernalillo County and is situated in the central part of the state, straddling the Rio Grande. Its modern Downtown core contrasts with Old Town, dating to the city’s 1706 founding as a Spanish colony. Old Town is filled with historic adobe buildings, such as San Felipe de Neri Church, and shops selling Native American handicrafts. The Indian Pueblo Cultural Center traces the area’s tribal history.

Dallas is the third-largest city in Texas and the ninth-largest in the United States. Divided between Collin, Dallas, Denton, Kaufman, and Rockwall counties, the city had an estimated 2009 population of approximately 1.3 million, according to the United States Census Bureau. The city is the largest economic center of the 12-county Dallas–Fort Worth–Arlington metropolitan area that according to the March 2010 U.S. Census Bureau release, had a population of roughly 6.5 million as of July 2009. The metropolitan area is the largest metropolitan area in the South and fourth-largest metropolitan area in the United States.

Honolulu, on Oahu’s south shore, is the main gateway to Hawaii and a major gateway into the United States. The city is a major hub for international business, military defense, as well as famously being host to a diverse variety of east-west and Pacific culture, cuisine, and traditions. The name Honolulu means "sheltered harbor" or "calm port".

Sacramento, capital of the U.S. state of California, is at the confluence of the Sacramento River and the American River in the northern portion of California's expansive Central Valley. Dubbed as "America's Most Diverse City", it is the cultural and economic core of the Sacramento metropolitan area. During the California Gold Rush, Sacramento was a major distribution point, a commercial and agricultural center, and a terminus for wagon trains, stagecoaches, riverboats, the telegraph, the Pony Express, and the First Transcontinental Railroad. The city was named after the Sacramento River, which forms its western border. The river was named by Spanish cavalry officer Gabriel Moraga for the Santísimo Sacramento (Blessed Sacrament), referring to the Catholic Eucharist. California State University, Sacramento, more commonly known as Sacramento State or Sac State, is the largest university in the city and one of 23 campuses in the California State University system. University of the Pacific's Sacramento Campus is a private university with one of its three campuses in Sacramento. In addition, the University of California, Davis, is in nearbyDavis, 15 miles (24 km) west of the capital. The UC Davis Medical Center, a world-renowned research hospital, is located in the city of Sacramento.

Minneapolis, nicknamed "City of Lakes" and the "Mill City," is the county seat of Hennepin County, the largest city in the U.S. state of Minnesota, and the 48th largest in the United States. Its name is attributed to the city's first schoolteacher, who combined mni, the Dakota word for water, and polis, the Greek word for city. Minneapolis lies on both banks of the Mississippi River, just north of the river's confluence with the Minnesota River, and adjoins Saint Paul, the state's capital. Known as the "Twin Cities," Minneapolis-St. Paul is the 16th-largest metropolitan area in the U.S., with 3.5 million residents. The Metropolitan Council estimated the city's population in 2008 as 390,131.

Washington, D.C., formally the District of Columbia and commonly referred to as Washington, the District, or simply D.C., is the capital of the United States founded on July 16, 1790. The U.S. Constitution allows for the creation of a special district to serve as the permanent national capital. The District is therefore not a part of any U.S. state and is instead directly overseen by the federal government. Within the District, a new capital city was founded in 1791 and named in honor of George Washington. The City of Washington, along with Georgetown and outlying areas within the federal district, were placed under a single, unified government following an act of Congress in 1871. It is for this reason that the city, while legally named the District of Columbia, is known as Washington, D.C. The city shares its name with the U.S. state of Washington located on the country's Pacific coast.

Columbus is the capital and largest city in the U.S. state of Ohio, center of the state's third largest metropolitan area behind Cincinnati and Cleveland, the fourth largest city in the American Midwest, and the sixteenth largest city in the United States of America. It is the county seat of Franklin County, yet the city has expanded and annexed portions of adjoining Delaware County and Fairfield County. Named for explorer Christopher Columbus, the city was founded in 1812 at the confluence of the Scioto and Olentangy rivers, and assumed the functions of state capital in 1816. The city has a diverse economy based on education, government, insurance, banking, fashion, defense, aviation, food, clothes, logistics, steel, energy, medical research, health care, hospitality, retail, and technology. Modern Columbus has emerged as a technologically sophisticated city.

Louisville, the largest city in the Commonwealth of Kentucky and the 30th-most populous city in the United States, is one of two cities in Kentucky designated as first-class. Louisville is the historical seat and, since 2003, the nominal seat of Jefferson County. It was founded in 1778 by George Rogers Clark and is named after King Louis XVI of France, making Louisville one of the oldest cities west of the Appalachian Mountains. Sited beside the Falls of the Ohio, the only major obstruction to river traffic between the upper Ohio River and the Gulf of Mexico, the settlement first grew as a portage site. An important internal shipping port in the 19th century, Louisville is today most well known for the Kentucky Derby, the widely watched first race of the Triple Crown of Thoroughbred Racing.

El Paso is the county seat of El Paso County, Texas, United States. The city is situated in the far western corner of the state of Texas. El Paso stands on the Rio Grande (Río Bravo del Norte) across the border from Ciudad Juárez, Chihuahua, Mexico. The city is also the headquarters of one Fortune 500 and three publicly traded companies, as well as home to the Medical Center of the Americas, the only medical research and care provider complex in West Texas and southern New Mexico, and the University of Texas at El Paso, the city's primary university. The city hosts the annual Sun Bowl college football post-season game, the second oldest bowl game in the country.

Baltimore is the largest independent city in the United States and the largest city and cultural center of the U.S. state of Maryland. The city is located in central Maryland along the tidal portion of the Patapsco River, an arm of the Chesapeake Bay. Baltimore is sometimes referred to as Baltimore City in order to distinguish it from surrounding Baltimore County. Founded in 1729, Baltimore is the largest U.S. seaport in the mid-atlantic and is situated closer to major Midwestern markets than any other major seaport on the East Coast. Baltimore's Inner Harbor was once the second leading port of entry for immigrants to the United States and a major manufacturing center. The harbor is now home to Harborplace, a shopping, entertainment, and tourist center, and the National Aquarium in Baltimore. According to Forbes, the city of Baltimore was rated 3rd best place to shop in 2010. After a decline in manufacturing, Baltimore shifted to a service-oriented economy. Johns Hopkins University and Johns Hopkins Hospital are now the city's largest employers.

Charlotte is the largest city in the U.S. state of North Carolina and the seat of Mecklenburg County. In 2009, Charlotte's population was estimated by the US Census Bureau as 709,441 (the Charlotte Chamber of Commerce insists it is higher in mid-2010, at 756,912), making it the 18th largest city in the United States based on population. The Charlotte metropolitan area had a 2009 population of 1,745,524. The Charlotte metropolitan area is part of a wider thirteen-county labor market region or combined statistical area with a 2009 estimated population of 2,389,763. Residents of Charlotte are referred to as "Charlotteans". $$https://www.youtube.com/watch?v=Qwn0Ni9G5ow$$

Colorado Springs is a Home Rule Municipality that is the county seat and most populous city of El Paso County, Colorado, United States. Colorado Springs is located in the South Central portion of Central Colorado. It is situated on Fountain Creek and is located 61 miles south of the Colorado State Capitol in Denver. At 6,035 feet the city sits over one mile above sea level, though some areas of the city are significantly higher. Colorado Springs is situated near the base of one of the most famous American mountains, Pikes Peak, at the eastern edge of the southern Rocky Mountains. With a 2010 Census of 416,427, it is the second most populous city in the state of Colorado, behind Denver, and the 46th most populous city in the United States, while the Colorado Springs Metropolitan Statistical Area had an estimated population of 626,227 in 2009. The city covers 186.1 square miles, making it Colorado's largest city in area. $$https://www.youtube.com/watch?v=EoK0YviLCh0$$

Tulsa is the second-largest city in the state of Oklahoma and 47th-largest city in the United States. With a population of 391,906 as of the 2010 census, it is the principal municipality of the Tulsa Metropolitan Area, a region with 937,478 (2010) residents in the MSA and 988,454 in the CSA Tulsa's CSA is projected to reach one million between 2010 and 2012. The city serves as the county seat of Tulsa County, the most densely populated county in Oklahoma, and extends into Osage, Rogers, and Wagoner counties. Tulsa was first settled in the 1830s by the Lachapoka Band of Creek Native American tribe. In 1921, it was the site of the infamous Tulsa Race Riot, one of the largest and most destructive acts of racial violence in the history of the United States. For most of the 20th century, the city held the nickname "Oil Capital of the World" and played a major role as one of the most important hubs for the American oil industry. Tulsa, along with several other cities, claims to be the birthplace of U.S. Route 66 and is also known for its Western Swing music. $$https://www.youtube.com/watch?v=NUE5LPDEOCc$$

Raleigh is the capital city and the second largest city in the state of North Carolina as well as the seat of Wake County. Raleigh is known as the "City of Oaks" for its many oak trees. According to the U.S. Census Bureau, the city's estimated population on November 22, 2010 was 426,708, over an area of 142.8 square miles, making Raleigh currently the 45th largest city in the United States. It is also one of the fastest growing cities in the country. The city of Raleigh is named after Sir Walter Raleigh. Raleigh, Durham, and Chapel Hill make up the three historically primary cities of the Research Triangle metropolitan region. The regional nickname of "The Triangle" originated after the 1959 creation of the Research Triangle Park, primarily located in Durham County, four miles from Downtown Durham and encompassed on three sides by the city of Durham and roughly midway between the cities of Raleigh and Chapel Hill and the three major research universities of NC State University, Duke University, and UNC-Chapel Hill.

Pittsburgh is the second-largest city in the U.S. Commonwealth of Pennsylvania and the county seat of Allegheny County. Regionally, it anchors the largest urban area of Appalachia and the Ohio River Valley, and nationally, it is the 22nd-largest urban area in the United States. The estimated population of the city in 2009 was 311,647, while the seven-county metropolitan area was estimated at 2,354,957. Downtown Pittsburgh retains substantial economic influence, ranking at 25th in the nation for jobs within the urban core and 6th in job density. The characteristic shape of Pittsburgh's central business district is a triangular tract carved by the confluence of the Allegheny and Monongahela rivers, which form the mighty Ohio River. The city features 151 high-rise buildings, 446 bridges, two inclined railways, and a pre-revolutionary fortification. Pittsburgh is known colloquially as "The City of Bridges" and "The Steel City" for its many bridges and former steel manufacturing base.

Oklahoma City is the capital and largest city of the state of Oklahoma. The county seat of Oklahoma County, the city ranks 27th among United States cities in population. The city also ranks as the eighth-largest city in the United States by land area (including consolidated city-counties; it is the largest city in the United States by land area whose government is not consolidated with that of a county or borough). Lying in the Great Plains region, the city features one of the largest livestock markets in the world. Oil, natural gas, petroleum products and related industries are the largest sector of the local economy. The city is situated in the middle of an active oil field and oil derricks dot the capitol grounds. Oklahoma City is on the I-35 Corridor and is one of the primary travel corridors into neighboring Texas and Mexico. Located in theFrontier Country region of the state, the city's northeast section lies in an ecological region known as the Cross Timbers. The city was founded during the Land Run of 1889, and grew to a population of over 10,000 within hours of its founding.

Charleston is a city in the U.S. state of South Carolina and is the second largest city in the state. The city lies just south of the geographical midpoint of South Carolina's coastline and is located on Charleston Harbor, an inlet of the Atlantic Ocean formed by the confluence of the Ashley and Cooper Rivers, or, as is locally expressed, "where the Cooper and Ashley Rivers come together to form the Atlantic Ocean." Founded in 1670 as Charles Town in honor of King Charles II of England, Charleston adopted its present name in 1783, and is defined by its cobblestone streets, horse-drawn carriages and pastel antebellum houses, particularly in the elegant French Quarter and Battery districts. 

Orlando is a major city in the central region of the U.S. state of Florida. It is the county seat of Orange County, and the center of the Greater Orlando metropolitan region. The Orlando metropolitan area has a population of 2,082,628 and it is the 27th largest metropolitan area in the United States, the 5th largest metropolitan area in the Southeastern United States, and the 3rd largest metro area in Florida. The city-proper population is 235,860 making Orlando the 80th largest city in the "United States". It is Florida's fifth largest city by population. Orlando was incorporated on July 31, 1875, and became a city in 1885.  

Chicago is the largest city in the state of Illinois. Its metropolitan area, commonly named "Chicagoland", is the 27th most populous metropolitan area in the world, home to an estimated 9.7 million people spread across the U.S. states of Illinois, Indiana and Wisconsin. Chicago is the county seat of Cook County, the second largest county in the United States by population. The city is renowned for its fascinating museums - including the Art Institute and its expansive collections, including noted Impressionist works; it is a city with an appetite for food, of course, but also for design, history, culture, finance, commerce, industry, technology, telecommunications and transportation.

San Diego, named after Saint Didacus, is the eighth-largest city in the United States and second-largest city in California after Los Angeles, with a population of 1,306,300 (Jul 2009) within its administrative limits on a land area of 372.1 square miles (963.7 km2). The city is located on the coast of the Pacific Ocean in Southern California. The urban area of San Diego extends beyond the administrative city limits with a population of 2,880,000. San Diego is also the county seat of San Diego County, the 5th largest county, by population, in the United States.   

Los Angeles, Spanish for "The Angels", is the most populous city in California and the second most populous in the United States, with a population of 4.06 million on a land area of 498.3 square miles (1,290.6 km2). It is the focal point of the larger Los Angeles-Long Beach Riverside  combined statistical area, which contains nearly 17.8 million people. This makes it the 12th most populous metropolitan area in the world. Los Angeles is also the seat of Los Angeles County, the most populated and one of the most multicultural counties in the United States. The city's inhabitants are referred to as "Angelenos".

Austin is the capital city of the U.S. state of Texas and the county seat of Travis County. Located in Central Texas on the eastern edge of the American Southwest, it is the fourth-largest city in Texas and the fifteenth most populous city in the United States. It was the third-fastest-growing large city in the nation from 2000 to 2006. Austin has a population of 786,386 (2009 U.S. Census estimate). The city is the cultural and economic center of the Austin–Round Rock–San Marcos metropolitan area, with a population of over 1.7 million, making it the 35th-largest metropolitan area in the United States.

Nashville is the capital of the U.S. state of Tennessee and the county seat of Davidson County. It is located on the Cumberland River in Davidson County, in the north-central part of the state. The city is a center for the health care, music, publishing, banking and transportation industries, and is home to a large number of colleges and universities. Nashville is the home of the Country Music genre and is dubbed "Music City".

Memphis, along the Mississippi River in Tennessee, is the youngest of Tennessee's major cities, founded in 1819 as a planned city by a group of wealthy Americans including judge John Overton and future president Andrew Jackson. A resident of Memphis is referred to as a Memphian, and the Memphis region is known, particularly to media outlets, as Memphis and the Mid-South. It is also known for its music and food.

Fort Worth is the 16th-largest city in the United States and the fifth-largest city in the state of Texas. The city is located in North Central Texas and covers nearly 350 square miles (910 km2) in Tarrant, Denton, Parker, and Wise Counties; it is the seat of Tarrant County. The city is the second-largest in the Dallas–Fort Worth–Arlington metropolitan area (the "DFW Metroplex"). The city was established in 1849 as an Army outpost on a bluff overlooking the Trinity River. Today, Fort Worth still embraces its Western heritage and traditional architecture and design. USS Fort Worth (LCS-3) is the first ship of the United States Navynamed after the city. Fort Worth is home to the Van Cliburn International Piano Competition and several world-class museums designed by internationally known contemporary architects. The Kimbell Art Museum, considered to have one of the best collections in Texas, is housed in what is widely regarded as one of Texas' foremost works of modern architecture, designed by Louis Kahnwith an addition by Renzo Piano.

Seattle is the northernmost major city in the contiguous United States, and the largest city in the Pacific Northwest and in the state of Washington. A seaport situated on a narrow isthmus between Puget Sound (an arm of the Pacific Ocean) and Lake Washington, about 100 miles (160 km) south of the Canada – United States border, it is named after Chief Sealth "Seattle", of the Duwamish and Suquamish native tribes. Seattle is the center of the Seattle–Tacoma–Bellevue metropolitan statistical area, the 15th largest in the United States, and the largest in the northwestern United States. Seattle is the county seat of King County and is the major economic, cultural and educational center in the region. The 2010 census found that Seattle is home to 630,320 residents within a metropolitan area of some 3.4 million inhabitants. The Port of Seattle and Seattle–Tacoma International Airport are major gateways to Asia, Alaska, and the rest of the world.

The City and County of Denver is the capital and the most populous city of the U.S. state of Colorado. It is a consolidated city-county, located in the South Platte River Valley on the western edge of the High Plains just east of the Front Range of the Rocky Mountains. The Denver downtown district is located immediately east of the confluence of Cherry Creek with the South Platte River, approximately 12.3 miles (20 km) east of the foothills of the Rocky Mountains. Denver is nicknamed the "Mile-High City" because its official elevation is exactly one mile or 5,280 feet (1,609.344 m) above sea level. The 105th meridian west of Greenwich passes through Union Station and is the temporal reference for the Mountain Time Zone.

Madison is the capital of the U.S. state of Wisconsin and the county seat of Dane County. It is home to the University of Wisconsin–Madison. It is also home to an extensive and varied number of print publications, reflecting the city's role as the state capital and its diverse political, cultural and academic population. In 1996, Money magazine identified Madison as the best place to live in the United States. It has consistently ranked near the top of the best-places list in subsequent years, with the city's low unemployment rate a major contributor.