New York City is the most populous city in the United States and the center of the New York metropolitan area. The city has a significant impact on global commerce, finance, media, culture, art, fashion, research, education, and entertainment. As host of the United Nations Headquarters, it is also an important center for international affairs. The city is often referred to as ''New York City'' or the ''City of New York'', to distinguish it from the state of New York, of which it is a part. Located on a large natural harbor on the Atlantic coast of the Northeastern United States, New York City consists of five boroughs: The Bronx, Brooklyn, Manhattan, Queens, and Staten Island. 

Eugene is the second largest city in the U.S. state of Oregon and the county seat of Lane County. It is located at the south end of the Willamette Valley, at the confluence of the McKenzie and Willamette rivers, about 50 miles east of the Oregon Coast. As of the 2010 U.S. Census, Eugene has a population of 156,185, and Lane County has a population of 351,715. While Eugene has long been the second largest city in Oregon, it was briefly surpassed by Salem between 2005 and 2007. The Eugene-Springfield, Oregon MSA is the 144th largest metropolitan statistical area of the U.S, and the third largest in the state, behind the Salem Metropolitan Area. Eugene is home to the University of Oregon. The city is also noted for its natural beauty, recreational opportunities, focus on the arts, activist political leanings, and residents with "alternative" lifestyles. Eugene's slogan is "A Great City for the Arts and Outdoors." It is also referred to as the "Emerald City", and "Track Town, USA." The Nike corporation had its beginnings in Eugene.

Baltimore is the largest independent city in the United States and the largest city and cultural center of the U.S. state of Maryland. The city is located in central Maryland along the tidal portion of the Patapsco River, an arm of the Chesapeake Bay. Baltimore is sometimes referred to as Baltimore City in order to distinguish it from surrounding Baltimore County. Founded in 1729, Baltimore is the largest U.S. seaport in the mid-atlantic and is situated closer to major Midwestern markets than any other major seaport on the East Coast. Baltimore's Inner Harbor was once the second leading port of entry for immigrants to the United States and a major manufacturing center. The harbor is now home to Harborplace, a shopping, entertainment, and tourist center, and the National Aquarium in Baltimore. According to Forbes, the city of Baltimore was rated 3rd best place to shop in 2010. After a decline in manufacturing, Baltimore shifted to a service-oriented economy. Johns Hopkins University and Johns Hopkins Hospital are now the city's largest employers.

Los Angeles, Spanish for "The Angels", is the most populous city in California and the second most populous in the United States, with a population of 4.06 million on a land area of 498.3 square miles (1,290.6 km2). It is the focal point of the larger Los Angeles-Long Beach Riverside  combined statistical area, which contains nearly 17.8 million people. This makes it the 12th most populous metropolitan area in the world. Los Angeles is also the seat of Los Angeles County, the most populated and one of the most multicultural counties in the United States. The city's inhabitants are referred to as "Angelenos".

Miami is a major city located on the Atlantic coast in southeastern Florida and the county seat of Miami-Dade County, the most populous county in Florida and the eighth-most populous county in the United States with a population of 2,500,625. The 42nd largest city in the United States, with a population of 433,136, it is the principal, central, and most populous city of the South {Florida} metropolitan area, the most populous metropolis in the Southeastern United States. According to the US Census Bureau, Miami's metro area is the seventh most populous in the United States, with an estimated population of 5,547,051 in 2009.