Boston is the capital of and largest city in Massachusetts, and is one of the oldest cities in the United States. The largest city in New England, Boston is regarded as the unofficial "Capital of New England" for its economic and cultural impact on the entire "New England" region. The city proper had a 2009 estimated population of 645,169, making it the twentieth largest in the country. It is also the anchor of a substantially larger metropolitan area called  "Greater Boston", home to 4.5 million people and the tenth-largest metropolitan area in the country. Greater Boston as a commuting region includes six Massachusetts counties:  "Essex", "Middlesex","Norfolk", "Suffolk", "Plymouth", "Worcester", northern "Bristol" County, all of "Rhode Island" and parts of "New Hampshire"; it is home to 7.6 million people, making it the fifth-largest Combined Statistical Area in the United States.

Philadelphia - Pennsylvania’s largest city, is notable for its rich history. It is the fifth-most-populous in the United States, with an estimated population in 2014 of 1,560,297. In the Northeastern United States, at the confluence of the Delaware and Schuylkill River, Philadelphia is the economic and cultural anchor of the Delaware Valley, a metropolitan area home to 7.2 million people and the eighth-largest combined statistical area in the United States. It is also home to many national historical sites that relate to the founding of the United States. Independence National Historical Park is the center of these historical landmarks being one of the country's 22 UNESCO World Heritage Sites.Independence Hall, where the Declaration of Independence was signed, and the Liberty Bell are the city's most famous attractions.

New York City is the most populous city in the United States and the center of the New York metropolitan area. The city has a significant impact on global commerce, finance, media, culture, art, fashion, research, education, and entertainment. As host of the United Nations Headquarters, it is also an important center for international affairs. The city is often referred to as ''New York City'' or the ''City of New York'', to distinguish it from the state of New York, of which it is a part. Located on a large natural harbor on the Atlantic coast of the Northeastern United States, New York City consists of five boroughs: The Bronx, Brooklyn, Manhattan, Queens, and Staten Island. 

Minneapolis, nicknamed "City of Lakes" and the "Mill City," is the county seat of Hennepin County, the largest city in the U.S. state of Minnesota, and the 48th largest in the United States. Its name is attributed to the city's first schoolteacher, who combined mni, the Dakota word for water, and polis, the Greek word for city. Minneapolis lies on both banks of the Mississippi River, just north of the river's confluence with the Minnesota River, and adjoins Saint Paul, the state's capital. Known as the "Twin Cities," Minneapolis-St. Paul is the 16th-largest metropolitan area in the U.S., with 3.5 million residents. The Metropolitan Council estimated the city's population in 2008 as 390,131.

Washington, D.C., formally the District of Columbia and commonly referred to as Washington, the District, or simply D.C., is the capital of the United States founded on July 16, 1790. The U.S. Constitution allows for the creation of a special district to serve as the permanent national capital. The District is therefore not a part of any U.S. state and is instead directly overseen by the federal government. Within the District, a new capital city was founded in 1791 and named in honor of George Washington. The City of Washington, along with Georgetown and outlying areas within the federal district, were placed under a single, unified government following an act of Congress in 1871. It is for this reason that the city, while legally named the District of Columbia, is known as Washington, D.C. The city shares its name with the U.S. state of Washington located on the country's Pacific coast.

Chicago is the largest city in the state of Illinois. Its metropolitan area, commonly named "Chicagoland", is the 27th most populous metropolitan area in the world, home to an estimated 9.7 million people spread across the U.S. states of Illinois, Indiana and Wisconsin. Chicago is the county seat of Cook County, the second largest county in the United States by population. The city is renowned for its fascinating museums - including the Art Institute and its expansive collections, including noted Impressionist works; it is a city with an appetite for food, of course, but also for design, history, culture, finance, commerce, industry, technology, telecommunications and transportation.